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On March 9, 2012
Last modified:June 12, 2012


Bioperine (black pepper extract)


Bioperine, or black pepper extract, contains piperine and has multiple health benefits on top of being a staple household spice. It is also used in exercise supplements to increase absorption and enhance nutrient bioavailability.


Reported Effects

1) Improves nutritional benefits.

2) Enhances production of heat in the body.

3) Helps break down fat cells.


Some of the more common effects and benefits of bioperine include:

Absorption – when a nutrient is not absorbed by the body, it becomes a waste even upon ingestion. Bioperine has been proven to assist in such a task, which is essential in order to get the most out of the nutrition that we get from food and supplements.

This may prove to be a good advantage when bodybuilding or exercising, as your body is able to maximize the benefits that are being provided by supplements and vitamins.

Thermogenesis – it enhances the production of heat in the body, which in turn increases the energy that is available for use.

Helps stimulate breakdown of fat cells – it stimulates gastric secretions, which have a direct impact on increasing the metabolic rate of the body. Spicy food in general raises the metabolic rate by about 8% even hours after ingestion. An increased metabolic rate leads to the body burning more calories in a shorter period of time, which in turn results to weight loss.


More benefits include:

- Elimination of hemorrhoids

- Alleviates gas and constipation

- Promotes urination

- Prevents migraines and headaches


Possible Dangers

Excessive use of Bioperine may lead to gastrointestinal issues such as vomiting, diarrhea and nausea. In most cases, these are mild manifestations and should not be a cause for too much alarm. Excessive intake may also cause heartburn on top of irritation of the stomach.

The powdered form should not come into contact with the eyes, as this will definitely cause irritation. If inhaled, it may also irritate the lungs.


FDA Approved?

The FDA has approved black pepper, black pepper oil, and piperine as Generally Recognized as Safe for use in food.



There is a lack of conclusive research and study involving human subjects, and this would definitely be needed in order for us to get a better understanding of the benefits and side effects.

There was a study at the Agharkar Research Institute in Pune, India indicating that this compound may interfere with reproductive fertility, but this test was conducted on mice. The test also showed that the litters were much smaller, and there was an effect on the production of sperm on male mice.


Other tests and trials provided the following results:

1. 14 days supplementation resulted to increased serum levels of coenzyme Q10, which is beneficial for the heart, Parkinson’s disease, and other health issues.

2. Curcumin bioavailability was increased 2000%. This, in turn, has positive effects as being an antioxidant and antitumor.

3. Vitamin B6 levels have increased by three times when the vitamin is taken with Bioperine. B6 affects the intracellular processes of the body, which would mean better health.

4. Vitamin C plasma concentrations were also found to be higher when taken with Bioperine.


Supplements using this Ingredient:

1. Vegetable Greens

2. Bioperine (120 tablet) by Source Naturals

3. Doctor’s Best High Absorption CoQ10 w/ Bioperine

4. Kyolic Curcumin with Bioperine

5. Doctor’s Best Curcumin with Bioperine

6. Source Naturals Coenzyme Q10 30 MG w/ Bioperine

7. Nature’s Plus DHEA-25 w/ Bioperine, Vegetarian Capsules

8. Pure Encapsulations Curcumin 500 with Bioperine

9. Source Naturals Coenzyme Q10 30 MG w/ Bioperine

10. Natures Plus – DHEA-10 w/Bioperine



It almost comes as a shock that Bioperine, a compound that has a tremendous impact on nutrient absorption, could be found and extracted from a rather common spice. In any case, the benefits are very applicable to day-to-day life, and is most advantageous to people trying to build muscle mass through exercise and intense physical activity.

1, 3 Dimethylxanthine is another such compound which comes from humble roots, but has amazing medicinal properties.

Bioperine (black pepper extract)