Review of: Alpha-GPC

Reviewed by:
4 Stars
On April 4, 2012
Last modified:June 12, 2012




Alpha-GPC is a dietary supplement derived from highly purified soy. The nutrient is included in a number of supplemental medicines and performance enhancing formulas. Alpha-GPC is very beneficial to the nervous system, but it also has major disadvantages.


Reported Effects:

1)      Improves memory and learning functions

2)      Mental clarity

3)      Enhanced focus and alertness

4)      Improves mood


What is Alpha-GPC and  how does it affect the body?

Alpha-GPC, or Glycerylphosphorylcholine as it is chemically known, is released during the breakdown of a particular fatty acid present in soy and some other plants. Presence of Alpha-GPC results in increased production of the neurotransmitter Acetylcholine. More neurotransmitters results in a more efficient nervous system, hence boosting memory and learning abilities.

In more technical terms, Alpha-GPC is a phospholipid metabolite required mainly in neuronal membranes. In the brain it triggers learning processes by accelerating production and secretion of acetylcholine. Acetylcholine is used for communication between neurons; an increased concentration improves transmission of nerve impulses.

Alpha-GPC is also responsible for enhancing the production of growth hormones at the pituitary gland by stimulating master hormones. This results in an interesting application: Intake of Alpha-GPC boosts recovery from strokes, injuries and anesthesia.

In Europe Alpha-GPC is frequently used as a prescription drug for treating Alzheimer disease. In the US, the use is more common in dietary supplements and to improve memory. It is recommended for individuals aiming to improve their thinking skills and learning abilities.

All scientific studies agree that choline concentration diminishes in the human body with age. This reduces the efficiency of the nervous system. Because of this reason, Alpha-GPC is particularly important for adults and the elderly.


What clinical studies support the use of Alpha-GPC?

According to the issue of Mechanisms of Ageing and Development, an extensive research on 4, 054 patients was conducted in 2011 which were suffering from various brain disorders, strokes, Alzheimer diseases and transient ischemic attacks. The conclusion drawn from this study strongly proved that the usage of Alpha-GPC significantly improves the patient’s clinical condition.


What is the recommended dosage?

The usual recommended amount for Alpha-GPC is one 300mg capsule a few times a week as recommended by your qualified health consultant. Studies do not specify regarding the right amount of dosage. The appropriate dose depends on a number of factors such as the user’s age and health condition. It is best to avoid high doses as this may cause nausea, over-stimulation, high blood temperature and insomnia.


What are the dangers of using Alpha-GPC?

There are significant side effects caused by Alpha-GPC to some patients. It can cause potential weight gain and loss of appetite. Skin rashes, heartburn, insomnia, dizziness and confusion are also frequently reported. Alpha-GPC is considered to generate symptoms of depression and individuals who feel more depressed after consumption should discontinue use and consult a physician. Alpha-GPC should be particularly avoided by pregnant and nursing women.


Alternative names for this ingredient:

1)      Alpha Glycerol Phosphoryl Choline

2)      Alpha-Glyceryl Phosphatidylcholine

3)      L-A-Glyceryl Phosphorylcholine


Supplements using this ingredient:

1)     Jarrow Alpha-GPC 300mg

2)    Source Naturals Alpha-GPC 300mg

3)    Now Alpha-GPC 300mg



Keep in mind to follow the relevant details on product labels as Alpha-GPC can harm you if you treat it carelessly. It is best to follow the recommendation from your doctor or professional health consultant as misuse can cause significant side effects such as insomnia, nausea, diarrhea, chest pain and breathlessness.

Alpha-GPC is a useful and high-performance nutrient, but should only be used after proper consultation with a qualified nutritionist. A related ingredient to check out is Choline which is quite effective itself.